Here's a detailed guide for the Sanctum of Rainbow Spirits Domain in "Genshin Impact":
Domain Information:
•Location: In Natlan, specifically in the Toyac Springs area, near the southwestern part of the region.
•Type: Domain of Blessing, aimed at providing Artifact Sets.
How to Unlock:
•Adventure Rank: Requires Adventure Rank 22 to unlock.
Unlocking:
•No puzzle required. Approach the domain from the Tequemecan Valley waypoint, follow the main road westward, then curve southward towards Toyac Springs. The domain is easily visible by the main road.
Enemies:
Primary Enemies:
•Pyro Slimes - Common, apply Pyro for Burning or Melt reactions.
•Pyro Abyss Mages - Shielded, can heal or buff themselves; breaking their shields is crucial.
•Pyro Hilichurl Rogues - Use Pyro for ranged attacks, adding mobility and ranged threat.
•Blazing Axemaster - Natlan-specific enemy, deals massive Pyro damage with area attacks.
Domain Step-by-Step Walkthrough: 
Preparation:
•Build a team with effective Pyro counters. Cryo for Melt, Hydro for Vaporize, and Electro for Overload reactions are highly beneficial due to the domain's focus on Pyro enemies.
Levels:
•Levels I - IV: Difficulty increases with each level:
•Level I: Mainly Pyro Slimes, quick to manage.
•Level IV: Includes all enemy types with increased stats, requiring more strategic play.
Ley Line Disorder:
•Ley Line Disorder: Characters gain a 75% Pyro DMG Bonus, promoting Pyro damage strategies but also making you more susceptible to Pyro reactions.
Rewards Schedule:
Artifact Sets:
•Obsidian Codex - Enhances DMG when in the Nightsoul's Blessing state, part of Natlan's unique mechanics.
•Scroll of the Hero of Cinder City - Provides energy regeneration and Crit Rate boost when consuming Nightsoul Points.
•Other Rewards: Mora, Adventure EXP, and Companionship EXP. Rewards require 20 Original Resin to claim.
5 Strategies for Sanctum of Rainbow Spirits: 
•Elemental Reaction: Utilize Cryo or Hydro for strong reactions against Pyro enemies.
•Shield Utilization: Characters like Zhongli or Noelle offer protection against Pyro damage.
•Crowd Control: Anemo characters like Venti can group enemies for easier management.
•Burst Timing: Save your elemental bursts for when shields are down or enemies are grouped.
•Nightsoul Mechanic: Characters with abilities that interact with Nightsoul can benefit greatly from the artifact sets.
5 Tips for Sanctum of Rainbow Spirits: 
•Mage Priority: Always tackle the Pyro Mages first to prevent them from becoming more problematic.
•Positioning: Use the terrain to avoid being hit by the Blazing Axemaster's wide area attacks.
•Artifact Farming: Aim for Level IV for the highest chance of 5-star artifacts, but expect a tougher challenge.
•Reaction Control: Be mindful of where and when you trigger reactions to avoid harming your team.
•Healing: With Pyro being prevalent, keep a healer or use healing food to manage health
This guide should assist you in navigating and conquering the Sanctum of Rainbow Spirits Domain, optimizing your artifact farming in "Genshin Impact".
